The new MacBook Pro delivers a speed boost for complex simulations and data manipulation. Apple on Thursday announced updated MacBook Pro 13- and 15-inch notebooks with a Touch Bar, 8th-generation Intel Core processors, support for up to 32 GB of DDR memory in the larger notebook, a True Tone display, and an improved third-generation keyboard for quiet typing.The 15-inch model comes with 6-core Intel Core i7 and i9 processors rated at up to 2.9 GHz — with Turbo Boost, up to 4.8 GHz. It offers up to 4 TB of SSD storage.The 13-inch model has quad-core Intel Core i5 and i7 processors rated at up to 2.7GHz — with Turbo Boost up to 4.5 GHz. IT has double the eDRAM of its predecessors and up to 2 TB of SSD storage.SSD read speeds are up to 3.2GB/second. Both new MacBook Pros have up to 10 hours of battery life. Demand and Defection Security, Siri and the T2 Processor The True Tone screen technology, rated at 500 Nits, supports the P3 wide color gamut, as do the iPhone 7 and iMac Pro.”The TrueTone display is a nice touch for people who sit in front of their screens for hours on end — particularly for creatives, who really strain their eyes with their work,” Smith noted. Both update notebooks have Apple’s T2 chip, which debuted in the iMac Pro desktop earlier this year.The T2 supports secure boot and on-the-fly encrypted storage for greater security. It also enables the Siri voice assistant.”The real-time encryption makes it easier to protect your data,” said Kevin Krewell, principal analyst at Tirias Research.”I don’t think the Siri aspect is all that important, but it does level the field with Microsoft’s Cortana support,” he told TechNewsWorld.The processors aren’t new. Apple began using AMD Radeon in 15-inch MacBook Pros back in 2016, and the T2 processor in the iMac Pro desktop released earlier this year. MacBook Pros released in 2016 had Thunderbolt 3 ports. “There’s a lot of pent-up demand out there for an updated MacBook Pro, but there’s also been evidence of Mac users defecting to Windows machines in recent years,” Smith said.The updates “will give Mac sales a little boost over the next year,” he said.Some users might be upset that the MacBook Pros only offer the Thunderbolt port, “but Apple included [up to] four of these,” Smith noted, “and, frankly, it seems a little antiquated to still be complaining about ports that have been around for several years.”The Touch Bar “remains somewhat controversial, and only minor upgrades are available on the non-Touch Bar model,” he said. Also, “it sounds like incremental improvements were made to the keyboard but that some issues persist.” Pricing and Availability Richard Adhikari has been an ECT News Network reporter since 2008. His areas of focus include cybersecurity, mobile technologies, CRM, databases, software development, mainframe and mid-range computing, and application development. He has written and edited for numerous publications, including Information Week and Computerworld. He is the author of two books on client/server technology. Email Richard. “The processor and RAM upgrades are crucial to keeping up with competitors on very premium devices like this,” said Eric Smith, director of tablet and touchscreen strategies at Strategy Analytics.”HP, Microsoft, and even Huawei have all made hay of how much more power their premium laptops have over Apple,” he told TechNewsWorld.Other features include an AMD Radeon Pro graphics card in the 15-inch MacBook Pro, as well as Touch ID, dynamic stereo speakers, and up to four Thunderbolt 3 ports. The new MacBook Pros are featured in Apple’s Back to School promotion, which launched Thursday. Purchasers will get educational pricing for the Mac, iPad Pro, AppleCare, select accessories, and a pair of qualifying Beats headphones free with the purchase of any eligible Mac or iPad Pro.The updated 13-inch MacBook Pro starts at US$1,800 and the updated 15-inch model at $2,400. Both are available at Apple.com, and at select Apple Stores and Apple Authorized Resellers.A maxed-out 15-inch updated MacBook Pro costs $6,700, according to AppleInsider.That might seem pricey, but MacBook Pros are a critical tool for professionals, Tirias’ Krewell pointed out. “They are not as price-sensitive, and Apple knows it.”Microsoft has a $3,300 Surface Book 2 with 1 TB of storage, 16 GB of RAM and a discrete GPU, Strategy Analytics’ Smith noted. “By leapfrogging many of these specs with an 8th Generation Core i9 processor, it’s not [impossible] that some well-heeled Mac enthusiasts who value a powerful workstation will shell out for this.”The most interesting part of this announcement “was the extension of [Apple’s] portfolio upwards with more build-to-configuration options,” observed Linn Huang, research director at IDC.”This is less about competing with a performance desktop market, and more about Apple tapping into the rapidly growing mobile workstation market, which grew more than 19 percent annually over the past two years,” he told TechNewsWorld.”The $7,000 i9 behemoth is less about moving a typical current MacBook Pro owner up the stack than it is about luring, for example, the Dell Precision Mobile Workstation user back to Apple,” Huang said.The iPhone is Apple’s main revenue generator, so whether Apple will remain committed to the MacBook is a question “only a few in Cupertino can answer,” he remarked.This is the device’s third iteration since its overhaul in 2016, Huang pointed out, and “if we’re still getting component bumps and feature adds in 2020 without a new design, that would suggest some focus is diverting elsewhere.”On the other hand, “if we exclude the iPhone from revenue, the Mac is one of the biggest contributors to Apple’s business,” noted Smith, “and is one of three hardware legs it relies on to make incremental services revenue.” Easy on the Eyes
A pure game play by Apple would be “hugely complicated, expensive and dangerous for the company,” maintained Charles King, principal analyst at Pund-IT, a technology advisory firm in Hayward, California.That risk is reduced if Apple acts as a broker in a Netflix-type model.”That’s considerably less fraught,” King told TechNewsWorld. “The company could kick off the service after inking agreements with game developers, but like Netflix, over time it could also develop its own unique games and deliver them with the service platform.”A subscription game offering could bolster services revenues significantly at a time when the company’s hardware sales appear to have plateaued, he added. “That should help calm investors and analysts who have helped drive the company’s stock price down.”In 2018, consumer global spending on games was $129 billion, according to Piers Harding-Rolls, director at IHS Markit, a research, analysis and advisory firm headquartered in London.”Games are very sticky, drive device usage, and are globally appreciated,” he told TechNewsWorld.”For the leading tech companies, having a games service strategy is as important as having a video or music service strategy,” Harding-Rolls continued. “If Apple is confirmed to be working on a gaming service, it could help drive adoption of its devices, reduce churn, and also drive direct services revenue.” A video game sells for around $60. A streaming service charges $10 to $15 a month per subscriber. That money needs to be split among multiple publishers, Goodman noted.”As a result of that, publishers have been more than willing to make back catalogs that are no longer selling available to streaming game services, but not new releases, and it is the new releases that drive the market,” he explained.The player best positioned to make streaming work is Microsoft, Goodman maintained. “Given all the internal game development studios they own, they can seed any streaming service with new releases from internal sources.”However, “subscription gaming” need not mean streaming gaming.”Considering where Apple is today, I would venture to assume it’s considering an app-based model rather than a new cloud gaming service,” said Michael Inouye, principal analyst at Scottsdale, Arizona-based ABI Research, a technology advisory company.An app-based model typically allows a subscriber to download all the games they want and play them as long as their subscription remains active.”Subscription services are gaining popularity across content markets from video to music and gaming, so it could offer value to the mobile gaming segment as well,” Inouye told TechNewsWorld.”Even if Apple does not launch a subscription service,” he added, “it still behooves the company to explore this model because of the success other markets are experiencing, and to ensure they remain competitive.” Calming Investors What’s more, big players like Amazon and Google have announced their intentions to join current kingpins Microsoft and Sony in the streaming market, Cole said. “It’s a very competitive landscape.”Apple’s audience for the service — primarily users of its phones and tablets — may not go flocking to it, either, he continued.”Xbox and PlayStation consumers are heavy-duty gamers. They’re willing to plunk down (US)$400 for a game system and $60 apiece for a game, and it’s still tough to get them to pay for a subscription service,” Cole observed.”Apple faces the same challenge, but their consumer is not going to be into the games as much as a consumer who has bought an Xbox or PlayStation,” he pointed out. “Charging a Netflix-like monthly subscription fee is really tough. Anything over $5 a month is a lot.” Apple will tailor its service to its user base, predicted Mark N. Vena, senior analyst at Moor Insights and Strategy, a technology analyst and advisory firm based in Austin, Texas.”I suspect Apple will be going after more mainstream, family-oriented types of games. It’s hard for me to believe that they’ll go after hard-core games, where the gaming is first-person shooter and more violent,” he told TechNewsWorld. “They’ll probably target casual users — users who play sports-oriented games, trivia games, games that don’t require a lot of graphics power.”The move could be a good one for Apple, Vena said. “If they stay in their lane and focus on phone and tablet mainstream games, and stay away from ultraviolent games, which would sully their brand, it will broaden their service appeal.” A move into subscription gaming seems to fit in with Apple’s media strategy, noted Ross Rubin, principal analyst at Reticle Research, a consumer technology advisory firm in New York City.”Apple is making lots of moves to offer subscription services in all major media,” he told TechNewsWorld.”They have music. They acquired a company that offered all-you-can-eat magazine subscriptions. They’re working on a video service. So this would be consistent with that,” Rubin said.”With 5G and faster 4G networks coming, that’s going to lend itself very well to launching streaming game services,” he noted. “Regardless of whether Apple does it or not, we’re going to see many more companies launch streaming game services because latency — which is key for this kind of service — will be lower than it has ever been on a cellular network.”Latency can make a video streaming service frustrating, but it typically doesn’t outright ruin the experience, said Billy Nayden, research analyst at Dallas-based Parks Associates, a market research and consulting company specializing in consumer technology products.That’s not the case with streaming games, however.”Because of the responsiveness required to play video games, latency issues are far more crippling,” Nayden told TechNewsWorld. “Apple must ensure their streaming service does not have any latency issues for that reason.” Good Strategic Fit The 5G Difference Focus on Casual Gamers A “Netflix for Games” type of service may be in Apple’s future. Apple has been developing a subscription service that will function for games much like Netflix does for movies and TV series, according to a Cheddarreport.It’s still unclear what the subscription fee would be or what kinds of games would be offered on the service, noted Cheddar, which bills itself as a “post-cable news, media, and entertainment company.”Whatever the fee for the offering, it could be tough for Apple to find an audience for a streaming service, maintained David Cole, an analyst at DFC Intelligence, a market research firm in San Diego.”Streaming was a huge topic six or seven years ago, when there were a lot of startups looking to get into the space,” he told TechNewsWorld. “What they found out was that people weren’t willing to pay a whole lot of money for that kind of service.” 5G could be a game-changer for streaming gaming, said Michael Goodman, director for digital media at Newton, Massachusetts-based Strategy Analytics, a research, advisory and analytics firm.”Over the past 15 to 20 years the landscape is littered with streaming game services that have tried and failed,” he told TechNewsWorld.”The big difference this time is 5G, which — at least in theory — should minimize, if not get rid of, latency issues associated with streaming gaming all together,” he said. “This is why we are seeing all these companies, such as Microsoft, Google, Amazon, Verizon, and now Apple, get excited by streaming.”Latency isn’t the only problem facing streaming gaming services, however.”Streaming game services just have not been able to come up with a licensing model that compensates publishers with lost retail revenue if they offer new releases via streaming services,” Goodman observed, Game Publishers Problem Tough Sell John P. Mello Jr. has been an ECT News Network reportersince 2003. His areas of focus include cybersecurity, IT issues, privacy, e-commerce, social media, artificial intelligence, big data and consumer electronics. He has written and edited for numerous publications, including the Boston Business Journal, theBoston Phoenix, Megapixel.Net and GovernmentSecurity News. Email John.
Reviewed by Alina Shrourou, B.Sc. (Editor)Oct 31 2018Veterans released from prison are five times as likely to attempt suicide as their peers who have never been incarcerated, report UConn Health researchers in an article slated for publication in the November 2018 print edition of the American Journal of Geriatric Psychiatry.”People over 50 are the fastest growing segment of the prison population, and most of them will eventually be released,” says UConn Health epidemiologist Lisa Barry.Regardless of a person’s age, release from prison increases the chance of death in the years immediately afterward. But older prisoners tend to have fewer friends and family around when they get released, and may find it even harder to reintegrate into the workforce than the average ex-prisoners, with the double stigma of being a former prisoner and being old.Knowing this, Barry and her colleagues suspected older ex-prisoners were at high risk of suicide attempts, but there was very little data available on the health of older, just-released prisoners.Related StoriesResearch suggests wisdom is linked to happiness and mental healthCannabis could help people with opioid addictionMental health care for elderly comes into focusResearchers worked with the Veteran’s Administration to get data from its Suicide Prevention Application Network (SPAN). SPAN tracks suicide attempts by veterans, and includes detailed information including time and date, mechanism of the attempt (hanging, drug overdose, etc.), and whether the veteran has any safety plan to prevent another attempt in the future.The researchers combined SPAN data with the medical records from Medicare and the VA of more than 14,000 people age 50 and older between 2012 and 2014.They found that approximately half had rejoined the community following incarceration during this time. The other half were counterparts of the same age and gender who had never been incarcerated.The results were sobering.When the researchers adjusted for conditions including brain trauma, mental illness, and homelessness (all additional risk factors for suicide), those who had been imprisoned were still three times as likely to attempt suicide. They were also more likely to die from accidental drug overdoses and other apparently accidental deaths.”The risk of suicide may be larger than we report. For some of those classified as dying by accident, was there some intent? We may never know,” Barry says. “But there needs to be awareness that this is a high-risk group, and perhaps a need for targeted prevention.”Barry and her colleagues are currently looking more closely at the healthcare services used by people who attempted suicide versus those who did not. They hope to find patterns that could help identify who is most at risk, and perhaps point to effective preventive strategies that health care providers serving the older population can use to help.Source: https://today.uconn.edu/2018/10/suicide-risk-heightened-among-older-vets-also-ex-cons/
Source:https://www.kcl.ac.uk/lsm/schools/basic-and-medical-biosciences/newsrecords/2018/nov/softer-trial-investigates-if-water-softeners-can-prevent-eczema.aspx Related StoriesRevolutionary gene replacement surgery restores vision in patients with retinal degenerationLoose double-stranded RNA molecules spur skin rejuvenationResearchers identify gene mutations linked to leukemia in children with Down’s syndromeThe team aim to recruit 80 women who live in hard water areas to the SOFTER trial during pregnancy if their unborn child is at high risk of having the condition, for instance, if they have a parent or sibling with eczema, asthma or hay fever. As part of the trial, the women are randomized to have a water softener installed in their homes or not. The softened water, which has minerals such as calcium and magnesium removed and replaced with sodium from common salt, is used to wash the babies.The researchers won’t know whether women had a water softener was installed in a baby’s home. They will look at a number of skin measurements in the babies, including water loss, pH levels, detergent deposits and skin bacteria. these will be taken from the baby at birth, one month, three months and six months to check for any changes to their skin. It is hoped this initial trial will lead the way for a larger-scale trial across the UK involving hundreds of patients. Reviewed by Alina Shrourou, B.Sc. (Editor)Nov 7 2018A clinical trial from the St John’s Institute of Dermatology, School of Basic & Medical Biosciences has been launched to investigate whether using water softeners can reduce the risk of eczema in babies.The trial is funded by the Biomedical Research Centre (BRC) and builds on findings from their previous research, published in 2017, showing that hard water damages the skin’s protective barrier and could contribute to the development of eczema.Eczema is a dry skin condition affecting one in five children and one in 12 adults. It comes in many forms, but symptoms can range from itchy, red skin to weeping or bleeding skin, which is at a high risk of infection. Living in a hard water area is known to increase the risk of having the condition.To understand whether water softeners might help to reduce this risk, the Softened Water for Eczema Prevention (SOFTER) trial will test whether using water softeners might help reduce the risk.Professor Carsten Flohr, consultant dermatologist St John’s Institute of Dermatology, is the chief investigator of the SOFTER study and is a programme lead at the BRC. He said: “The new study is exciting because it is the first time that researchers are looking at the effect of using water softeners on babies in their own homes. SOFTER builds on research published last year which found that eczema may be caused by hard water damaging the skin’s protective barrier. However, that study took place in a lab setting, focused on adults and was not randomized, so we hope that the SOFTER trial will give us a greater insight into whether water softeners can help infants avoid getting eczema, and allows us to gain more knowledge about the impact of hard water on babies’ skin.”
Source:https://www.elsevier.com/ Reviewed by James Ives, M.Psych. (Editor)Feb 28 2019Changes in food variety, portion size, dietary energy, and selected micronutrients are potentially fueling the obesity epidemic, according to a new study published in the Journal of the Academy of Nutrition and DieteticsDespite the addition of some healthful menu items, fast food is even more unhealthy for you than it was 30 years ago. An analysis of the offerings at 10 of the most popular US fast-food restaurants in 1986, 1991, and 2016, published in the Journal of the Academy of Nutrition and Dietetics, demonstrates that fast-food entrees, sides, and desserts increased significantly in calories and sodium and entrees and desserts in portion size over time. It also shows that while the variety of entree, sides, and dessert options soared by 226 percent, new or discontinued items tended to be less healthy than those available throughout the study period.”Our study offers some insights on how fast food may be helping to fuel the continuing problem of obesity and related chronic conditions in the United States. Despite the vast number of choices offered at fast-food restaurants, some of which are healthier than others, the calories, portion sizes, and sodium content overall have worsened (increased) over time and remain high,” said lead investigator Megan A. McCrory, PhD, Department of Health Sciences, Sargent College, Boston University, Boston, MA.Fast-food restaurants are on the rise around the world. In the US, about 37 percent of adults (aged >20 years) consume fast foods on any given day, and that increases to 45 percent for adults aged 20-39. One meal with an entree and side provides an average of 767 kcals, or close to 40 percent of a 2,000-calorie a day diet. Add a caloric beverage, and the amount increases to 45-50 percent of a person’s daily calorie intake. Dr. McCrory noted, “Given the popularity of fast food, our study highlights one of the changes in our food environment that is likely part of the reason for the increase in obesity and related chronic conditions over the past several decades, which are now among the main causes of death in the US.”Related StoriesJAMA commentary: Nutrition knowledge essential for today’s physiciansHarnessing target of the brain chemical serotonin to combat obesitySupervised fun, exercise both improve psychosocial health of children with obesityDr. McCrory and colleagues examined changes over the 30-year period from 1986 to 2016 in energy, portion size, energy density, sodium, iron, and calcium of menu items in entrees, sides, and desserts categories offered by 10 of the top fast-food restaurants (according to sales). Data were collected using The Fast Food Guide, published in 1986 and 1991, and online sources in 2016. The most significant findings were: The change in calcium and iron levels in some of the menu categories, in particular desserts, is a positive development since these nutrients are important for good bone mass and preventing anemia. However, the investigators stress that there are better sources that do not come with high calories and sodium. Dr. McCrory expressed a hope that the study’s findings would lead to higher awareness and creative solutions. “We need to find better ways to help people consume fewer calories and sodium at fast-food restaurants. The requirement that chain restaurants display calories on their menus is a start. We would like to see more changes, such as restaurants offering smaller portions at a proportional prices,” she concluded. Total number of entrees, desserts, and sides increased by 226 percent, or 22.9 items per year. Calories in all three categories increased significantly, with the largest increases in desserts (62 kcals per decade), followed by entrees (30 kcals per decade). These increases were mainly due to the increase in portion size, which was statistically significant in entrees (13 grams per decade) and desserts (24 grams per decade) categories. Sodium also increased significantly in all menu categories. At four of the 10 restaurants studied, information on calcium and iron content was available. Calcium increased significantly in entrees and desserts, while iron levels increased significantly in desserts.
Reviewed by Alina Shrourou, B.Sc. (Editor)Mar 30 2019Cells belonging to the body’s own immune system can help fight tumours. For several years now, this has allowed oncologists to use medications known as checkpoint inhibitors to encourage T cells to eliminate tumor cells. Last year the two scientists who discovered this therapeutic approach were awarded the Nobel Prize for Medicine.While doctors are enjoying some initial successes with this method, especially with regard to melanomas and several other types of cancer, immunologists and cancer researchers are working to develop the approach further. What they have in mind is a vaccine that would cause cancer-repelling T cells to multiply in the body, thereby strengthening the body’s immune defences. The big question is which molecules are suitable for a vaccine? Researchers working in the team of Manfred Kopf, Professor of Molecular Biomedicine, have now developed a method for identifying such molecules.The search for a rapport between immune cells and tumor cellsSince on the one hand tumours differ greatly from patient to patient, and on the other no two people (except identical twins) have the same immune system, future immunisation against cancer is a complex example of personalised medicine. The goal is to develop an individual vaccine for each patient.Potential vaccines include pieces of proteins, known as peptides, that are found only in tumours due to a mutation. Because T cells are specific and always recognise only one particular peptide, just as a key fits only one lock, a further prerequisite for a vaccine of this kind is that the patient has T cells capable of recognising these cancer peptides in the first place. So before doctors can immunise a cancer patient, laboratory tests must be conducted to search for corresponding pairs of T cells and peptides. A peptide that is recognised by a T cell can be used for personalised immunisation. The vaccine should then activate the T cells in the body that recognise only that peptide (and thus tumour cells). These T cells should ultimately wipe out the tumour.The ETH researchers’ method makes it possible for a laboratory to determine which T cells recognise which peptide. Up to now this has been incredibly difficult. The scientists used tumours in mice to show that their approach works. Next, they want to demonstrate the effectiveness of their approach in dealing with tumours in humans.Every patient gets their own set of reporter cellsAt the heart of this new method lies a collection of several million reporter cells, each one of which presents on its cell surface one of many peptides found in a tumour. The reporter cells are designed to turn green as soon as a T cell interacts with it due to recognition of the presented peptide. This enables the scientists to identify those tumour peptides that the T cells of a cancer patient recognises. This involves mixing the collection of reporter cells with T cells taken from the patient’s tumour, isolating the reporter cells that turn green and identifying the peptide they carry.Related StoriesNew protein target for deadly ovarian cancerUsing machine learning algorithm to accurately diagnose breast cancerTrends in colonoscopy rates not aligned with increase in early onset colorectal cancerSince each person (and each vertebrate generally) has a unique immune system, and since each tumour carries a unique pattern of mutations, the scientists must produce a different set of reporter cells for each patient. “One option is to determine the tumour’s genetic sequence and compare it with the gene sequence of the patient’s healthy cells,” Kopf says. This lets the researchers determine the extent to which the tumour differs from healthy tissue and then transfer the genetic information with precisely these tumor-specific differences into the reporter cells.Experimental testAs Kopf explains, “Other scientists are using computer predictions to try and find out which cancer peptides are suited to this type of immunization. But this approach is only as good as the algorithms used – and at the moment, they aren’t very reliable. By contrast, we have developed an experimental test that assures us that the T cells recognize patient tumor peptides.”Initial tests involving a breast cancer model in mice showed Kopf and his colleagues that their method works. In immunized mice, the immune system did indeed attack the tumor; in the non-immunised mice that the scientists used as a control, this did not happen.The scientists already patented this method five years ago. In 2015, their promising discovery won them ETH Zurich’s Spark Award. Their work was recently published in the specialist journal Nature Immunology.To develop commercial applications for the technique, the scientists founded an ETH spin-off called Tepthera. This start-up plans to demonstrate the effectiveness of their approach also using tumors in humans.Just as interesting for autoimmune diseases”Essentially, our technique and personalized immunization hold out promise for the treatment of all cancers – especially in combination with checkpoint inhibitors,” Kopf says, adding that the technology could also be used in the research and treatment of autoimmune diseases such as multiple sclerosis or type 1 diabetes.Unlike healthy people’s immune system, the immune system in people who suffer from autoimmune diseases attacks not only foreign or mutated cells, but also the autoimmune patient’s own body cells. In the case of many of these conditions, it is not yet known against which native molecules the autoimmune response is directed. This is something that can now be researched using the new method. In contrast to cancer, where the idea is to use immunization to activate the killer cells, for autoimmune diseases the aim is to develop a vaccine that tempers the immune system.Source: https://www.ethz.ch/en/news-and-events/eth-news/news/2019/03/individual-cancer-immunotherapy.html
Source:http://www.bristol.ac.uk/ Reviewed by Kate Anderton, B.Sc. (Editor)Apr 17 2019In the largest study of its kind, researchers from the Musculoskeletal Research Unit at the University of Bristol have identified the most important risk factors for developing severe infection after knee replacement. Patients who are under 60 years of age, males, those with chronic pulmonary disease, diabetes, liver disease, and a higher body mass index are at increased risk of having the joint replacement redone (known as revision) due to infection.The research, which follows their work on hip replacement published last year [20 November 2018], also showed that some patients are at higher risk of early infection whilst others are more prone to late infection after knee replacement. The study analyzed data from over 670,000 primary hip replacement patients, with 3,659 requiring revision for infection.The study, published in The Lancet Infectious Diseases today [Wednesday 17 April], conducted as part of the INFORM research programme funded by the National Institute for Health Research (NIHR) and the NIHR Bristol Biomedical Research Centre (BRC), considered the risk of infection following first-time (primary) knee replacement. This study used data from the National Joint Registry (NJR) for England, Wales, Northern Ireland and the Isle of Man linked to the Hospital Episode Statistics database.Knee replacement, used mainly to treat pain and disability caused by osteoarthritis, is a common procedure with around 110,000 operations performed annually in the UK. A rare but serious complication affecting about one per cent of patients is deep infection. This causes considerable distress and often requires long and protracted treatments including revision surgery.This study showed the reason for surgery, the type of procedure performed and the type of prosthesis and its fixation, influenced the risk of needing revision surgery for infection. Surgery performed following trauma, inflammatory arthropathy or a history of previous infection in the operated joint were more likely to be revised for an infection. Cemented total knee replacements were more likely to be revised for infection compared to patients with an uncemented implant. Finally, the risk of revision was increased for patients with a posterior stabilized fixed-bearing implant or a constrained condylar (CC) implant compared to those with an unconstrained (or cruciate retaining) fixed-bearing implant. The experience of the surgeon and the size of the orthopedic center had no or only small effects on the risk of revision for infection.Uniquely, the research identified that these important factors have a different effect depending on the post-operative period, with liver diseases or inflammatory arthropathy increasing the risk of revision for infection in the long-term but patients receiving a patellofemoral, unicondylar or uncemented total knee replacement had a lower risk of late revision for infection. This is an important factor to consider when conducting further research in this area as just considering overall risk or short-term risk may mean important effects are missed entirely.Related StoriesMini MRI device could help diagnose knee injuries more quickly and accuratelyArthroscopy more accurate than MRI for chondral defects of the knee, study findsBioventus and MTF Biologics collaborate to develop placental tissue product for knee osteoarthritisMichael Whitehouse, Reader and Consultant in Trauma and Orthopaedic Surgery in the Musculoskeletal Research Unit of the Bristol Medical School: Translational Health Sciences (THS), said: “This work has identified key patient and surgical characteristics which influence the risk of revision for infection following knee replacement, and specifically the risk of further surgery for infection two years or more after the initial operation. This information provides me with the strong evidence I need to discuss the risk of infection with my patients undergoing knee replacement and helps us identify strategies to minimize that risk for them.”Dr Erik Lenguerrand, Research Fellow in the Musculoskeletal Research Unit, added: “These findings are consistent with the results of our infection after hip replacement study and could be applied to a wide range of patients undergoing different implant surgery. Most of the risk factors identified are generally associated with a complex initial knee replacement. This should be considered by surgeons when planning their surgery to minimize the risk for their patients. We now have strong evidence to develop new patient resources with better information to help them discuss with their surgeon and make decisions about their treatment.”The researchers found the risk of revision for infection following primary knee replacement is affected by many different factors but is mainly driven by patient and surgical factors. The possible issues identified in this study should be considered by clinicians when preparing patients for knee replacement surgery.Further research should be carried out to find out if changes to the management of these conditions alters the risk of infection. It is equally important for clinicians to consider the issues that can’t be changed and the factors that show time specific effects on the risk of prosthetic joint infection, to support patients appropriately in their decision making pre-operatively and after they have undergone knee replacement.The research team will analyze further data from the NJR to look at the treatment of infection when it does occur to see what treatment has the best outcomes for patients.
According to the World Health Organization, childhood obesity is one of the most serious public health challenges of the 21st century. The problem is global and the prevalence has increased at an alarming rate. In 2016, more than 41 million children under the age of five were overweight.This study, based on the ELOIN cohort, examined the link between excess weight and high blood pressure in 1,796 four-year-olds who were followed up two years later. Blood pressure was measured at both time points, as was body mass index (BMI in kg/m2) and waist circumference.Compared to children maintaining a healthy weight between ages four and six, those with new or persistent excess weight according to BMI had 2.49 and 2.54 higher risks of high blood pressure, respectively. In those with new or persistent abdominal obesity, the risks for high blood pressure were 2.81 and 3.42 greater, respectively. Children who lost weight did not have an increased risk of high blood pressure. The findings applied to all children regardless of sex or socioeconomic status.Related StoriesDon’t Miss the Blood-Brain Barrier Drug Delivery (B3DD) Summit this AugustChaos in the house and asthma in children – the connectionGuidelines to help children develop healthy habits early in life”There is a chain of risk, whereby overweight and obesity lead to high blood pressure, which heightens the chance of cardiovascular disease if allowed to track into adulthood,” said Dr Galán. “But the results show that children who return to a normal weight also regain a healthy blood pressure.”The best way to maintain a healthy weight and lose excess kilos is to exercise and eat a healthy diet, said Dr Galán. In addition to the central role of parents, the school curriculum needs to include three to four hours of physical activity every week. Teachers should supervise activities during breaks, while schools can offer games and sports after classes and provide nutritionally balanced meals and snacks.Doctors should routinely assess BMI and waist circumference at early ages, added Dr Galán. “Some paediatricians think the harms of overweight and obesity begin in adolescence but our study shows they are mistaken,” he said. “We need to detect excess weight as soon as possible so the damaging impact on blood pressure can be reversed.”Overweight children should have their blood pressure measured. Three consecutive elevated readings constitute high blood pressure. In young children, the most common cause is excess weight, but doctors will rule out other reasons such as heart defects, kidney disease, genetic conditions, and hormonal disorders. If the cause is overweight, more activity and dietary improvements will be advised. If lifestyle changes don’t help, blood pressure lowering medication may be prescribed.Dr Galán noted that overweight in children is most accurately assessed using both BMI and waist circumference. In the study, using either measurement alone would have missed 15% to 20% of cases. The myth that excess weight in children has no consequences hampers the prevention and control of this health problem. Parents need to be more physically active with young children and provide a healthy diet. Women should shed extra pounds before becoming pregnant, avoid gaining excess weight during pregnancy, and quit smoking, as these are all established risk factors for childhood obesity.”Study author Dr Iñaki Galán, of Carlos III Health Institute, Madrid, Spain Reviewed by James Ives, M.Psych. (Editor)Jun 13 2019Overweight four-year-olds have a doubled risk of high blood pressure by age six, raising the hazard of future heart attack and stroke. That’s the finding of a study published today in the European Journal of Preventive Cardiology, a journal of the European Society of Cardiology (ESC). Source:European Society of Cardiology
Reviewed by Kate Anderton, B.Sc. (Editor)Jul 12 2019Many burn victims suffer acute kidney injury (AKI), but early recognition of AKI remains challenging. Now an Artificial Intelligence / Machine Learning (AI/ML) model developed at UC Davis Health and reported in a new study can predict acute kidney injury quicker and more accurately than ever. The ability to predict AKI in burn patients using AI is a potential breakthrough for burn centers. If we can tell that a patient might have kidney injury, we can institute measures to prevent it.”Tina Palmieri, professor and director of the Firefighters Burn Institute Regional Burn Center at UC Davis Medical Center What is acute kidney injury?Acute kidney injury (AKI) is sudden kidney failure or damage causing a build-up of waste in blood and a fluid imbalance in the body. AKI usually happens within the first week of serious burn due to inadequate resuscitation, especially during the critical first 24?hours. Developing in around 30% of cases, AKI is a common complication after severe burn, with a mortality rate reaching 80%.Diagnosing acute kidney injuryPhysicians typically rely on traditional biomarkers such as serum/plasma creatinine and urine output for diagnosis. However, urine output and creatinine measures are considered poor biomarkers of AKI.”UC Davis was the first to identify the role a novel biomarker, known as neutrophil gelatinase associated lipocalin (NGAL), plays in early prediction of AKI in severely burned patients,” said Nam Tran, associate clinical professor at Department of Pathology and Laboratory Medicine at UC Davis.Despite its strong predictive power, NGAL was not available in the United States and its interpretation required more experienced clinicians and laboratory experts. This challenge prompted the development of an artificial intelligence machine learning model to make it easier to interpret results for the NGAL test.Machine learning enhances acute kidney injury recognitionSometimes the assumption in the AI/ML world is that the more complicated algorithms such as deep neural network are better than more traditional algorithms in building ML models. This assumption is not always true.Related StoriesMachine learning identifies bugs that spread Chagas diseaseChronic kidney disease patients are excluded from clinical trialsCommon metric may not accurately assess kidney function of Indian patients”We built a powerful ML model through our k-Nearest Neighbor approach that is able to accurately predict AKI in our patient population in a much shorter period,” said Hooman Rashidi, professor in the Department of Pathology and Laboratory Medicine at UC Davis Health. “Based on admission data, the model can shorten the time to diagnosis by as much as two days.”The models were trained and tested with clinical laboratory data for 50 adult burn patients that had NGAL, urine output, creatinine and NT-proBNP measured within the first 24 hours of admission. Half of patients in the dataset developed AKI within the first week following admission. The models containing NGAL, creatinine, urine output and NT-proBNP achieved 90-100% accuracy for identifying AKI. The models containing only NT-proBNP and creatinine achieved 80-90% accuracy.The average time from admission to diagnosis with traditional biomarkers was 42.7 hours. The average time using the ML algorithm was just 18.8 hours. The ML model beat the traditional method by nearly a full day – critical time to prevent and treat AKI.”For our study, AI/ML has shown the potential clinical utility for predicting burn-related AKI when using just a few routine laboratory results,” Tran added.Applications and implications of the new modelThis model has applications to be used in the field, including for military casualties. Because troops might be sent to hospitals that lack the facilities to manage kidney injury, the AI/ML method could identify patients with AKI more quickly so they can be diverted faster to advanced medical facilities. This optimizes limited resources in the battlefield and accelerates the transport of patients to where they need to go. The same process applies in the civilian world.”We envision such machine learning platforms to be incorporated in a variety of settings outside of AKI which could ultimately enhance various aspects of patient care within the clinical medicine arena,” Rashidi added. Source:University of California – Davis HealthJournal reference:Tran, N.K. et al. (2019) Artificial intelligence and machine learning for predicting acute kidney injury in severely burned patients: A proof of concept. Burns. doi.org/10.1016/j.burns.2019.03.021.
Restaurant review newcomer The Infatuation is buying veteran Zagat from Google for an undisclosed amount Google paid $125 million for Zagat: WSJ This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Since Google bought Zagat a little more than six years ago for a reported $151 million, the long-established service for evaluating dining experiences has seen appetites turn to internet age services such as Yelp.”Zagat has helped us provide useful and relevant dining results for users across our various products,” Google vice president of product Jen Fitzpatrick said in a joint statement.”The Infatuation is an innovative company that will be a terrific home for the Zagat brand.”The Infatuation planned to cook the Zagat brand into its website and mobile application as part of a stated mission to become an influential global restaurant discovery platform.”Iconic brands don’t become available very often, and Zagat is about as iconic as it gets,” Infatuation co-founder and chief executive Chris Stang said.Zagat will remain a separate platform, working in tandem with The Information, according to the company.Zagat was founded in 1979 by Tim and Nina Zagat, serving restaurant ratings in printing guides and online. The team of reviewers grew, as did the types of industries covered in guides.The Infatuation launched in 2009, particularly targeting smartphone-generation restaurant seekers, and boasts reaching more than three million people monthly in an array of cities around world.”Tim and I are very excited for Zagat’s next chapter with The Infatuation,” Nina Zagat said. Explore further © 2018 AFP Citation: Zagat on menu for restaurant review site Infatuation (Update) (2018, March 5) retrieved 18 July 2019 from https://phys.org/news/2018-03-restaurant-platform-infatuation-zagat.html Restaurant review new-comer The Infatuation announced Monday a deal to buy veteran Zagat from Google for an undisclosed amount.
Citation: A step toward determining which car crashes cause traumatic brain injury—and which don’t (2019, April 23) retrieved 17 July 2019 from https://phys.org/news/2019-04-car-traumatic-brain-injuryand-dont.html Motor vehicle crashes are the most common cause of emergency room visits, hospitalizations and deaths related to traumatic brain injury among people aged 15 to 34, according to a 2013 report by the Centers for Disease Control and Prevention. More information: Seyed Saeed Ahmadisoleymani et al, Construction of a risk model through the fusion of experimental data and finite element modeling: Application to car crash-induced TBI, Computer Methods in Biomechanics and Biomedical Engineering (2019). DOI: 10.1080/10255842.2019.1574343 Traumatic brain injury, or TBI, makes up about 30 percent of all injury deaths in the United States, and early diagnosis and treatment is one of the most important ways to prevent these deaths.Aerospace and mechanical engineering professor Samy Missoum, who is also director of the Computational Design Optimization of Engineering Systems, or CODES Laboratory, and graduate student Seyed Saeed Ahmadisoleymani recently published a paper in Computer Methods in Biomechanics and Biomedical Engineering that details a new method for calculating the probability of a TBI due to a car accident.”Unlike with American football or military applications, there has not been much research done into the link between car crashes and TBI,” Missoum said. “We have developed the first steps of a method to assess the probability of TBI based on crash conditions, such as impact velocity and angle.”Combining Experimentation With Computational DataTBI research has traditionally involved experimental methods, such as conducting tests on animals or collecting data on football players. Other approaches are purely computational—for instance, using finite element models, which are mathematical tools to predict how a system like the brain will behave when subjected to external forces.Missoum’s approach fuses experimental and computational data. He uses experimental data to simulate how a dummy moves in a car crash and applies motion data from the simulation to a computer model of the brain to see how it would be affected. This fusion of data provides the basis for a method researchers hope will eventually be able to calculate the probability of TBI after a car crash.The method can even make predictions if researchers are unsure about the collision speed and angle of impact, or if they don’t have much information about the brain of the person involved in the crash.”From a scientific point of view, the novelty here is how we’re combining computational data and experimental data, while also accounting for several sources of uncertainty,” Missoum said. “From a practical point of view, the method provides a tool to determine the probability of TBI.”The work is in early stages, but one goal of the project is for first responders to be able to arrive at the scene of an accident and input the information about the crash into a tool, perhaps a mobile application, that will determine the probability of a TBI right away.”Let’s say a paramedic arrives at the scene of a car accident,” Missoum said. “They could input the information into a tool and say, ‘Okay, based on the characteristics of this accident, this person is going to have a 70 to 80 percent probability of severe traumatic brain injury.'”Machine Learning: A Key EnablerGetting into a car crash either will cause a traumatic brain injury or it won’t. The researchers used a machine learning approach previously developed in the CODES Laboratory to refine the threshold separating the two outcomes and more accurately determine the risk of TBI. In the future, this approach will improve accuracy further by increasing the number of factors it can consider, such as the weight of the vehicle or the age of the occupant.The research team hopes to incorporate data from actual car crashes, obtained from the Arizona Department of Transportation, into their research. Information like the angle of impact in a crash is not available in current crash reports, making this method’s ability to make calculations with a degree of uncertainty especially important. By combining computer simulations with experimental data, aerospace and mechanical engineering researcher Samy Missoum is developing a way to predict the likelihood of traumatic brain injury after a car crash. Credit: University of Arizona College of Engineering This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Provided by University of Arizona Analyzing data from more than 1 million teenagers sheds new light on how teens learn to drive Explore further
The findings address the need for efficient approaches to residential energy management by presenting a strategy that controls energy distribution. More specifically, the researchers propose a method that enables scheduling of electrical energy activities of smart homes connected in a microgrid to a distributor. This, they demonstrate, enables residents within the microgrid to distribute energy amongst each other in a way that lowers the overall load and demand for renewable energy.The research was published in the May issue of IEEE/CAA Journal of Automatica Sinica (JAS), a joint publication of the IEEE and the Chinese Association of Automation.Providing buildings and homes with a variety of small and grid-connected distributed energy resources is beneficial for several reasons. For one, it reduces energy loss in the process of distributing and transmitting energy from natural sources such as wind and sunlight. Also, wind and sunlight are not constant sources—sun can be blocked by clouds and winds change speed frequently. This means that the energy produced is not always used up completely. One way to address that is to store surplus energy, which can be expensive. Another alternative is connecting smart homes in a proactive way so that supply of electricity is balanced.In this study, the researchers focused on the scheduling of electrical energy activities of a microgrid made up of smart homes. The overall aim was to reduce the energy supply from the grid by allowing homes to exchange their surplus renewable energy and by optimally planning energy amounts used. Each smart home can both buy/sell energy from/to the grid. Simultaneously, smart homes cooperate and may buy/sell locally harvested renewable energy from/to other smart homes.”The proposed approach allows maximally exploiting the locally harvested energy, while ensuring that privacy about users’ consumption schedules is maintained,” adds Raffaele Carli, Ph.D., corresponding author and research fellow at Politecnico di Bari, Italy.The researchers propose a decentralized optimization algorithm, a system that enables each home within the grid to act as a single electricity load node. They demonstrate that this is the best approach that enables electricity use and use-scheduling so that any excess can be shared with other users within the network.In the future, the researchers hope to focus on improving estimations of the parameters that revolve around optimization. “The next step is to address a more complex scenario where residential users are eventually equipped with energy storage systems, whose capacities are reallocated among users. In this case the energy management aims at defining a control strategy that additionally ensures an optimal energy storage sharing, while simultaneously planning the consumption profile of the controllable appliances, the exchanged renewable energy among users, and energy to be bought/sold from the distribution network,” adds Carli. The ultimate goal is to increase efficiency in addressing the high demand for distribution and storage. ‘Smart’ transformers could make reliable smart grid a reality A group of Italian researchers has developed a method that enables more efficient use of energy by smart homes that are connected to a microgrid—a web of individualized units that are connected to one another and one common energy source. Credit: CC0 Public Domain This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. More information: IEEE/CAA Journal of Automatica Sinica, www.ieee-jas.org/article/doi/1 … 109/JAS.2019.1911462 Explore further Citation: Microgrids can help maximize efficiency of renewable energy consumption (2019, June 5) retrieved 17 July 2019 from https://phys.org/news/2019-06-microgrids-maximize-efficiency-renewable-energy.html Provided by Chinese Association of Automation
Jay Bruce injury update: Phillies outfielder (ribs) placed on injured list MLB wrap: Indians win, Twins lose as AL Central gap now smallest in 2 months MLB trade rumors: Phillies have been ‘in contact with every team that has pitching available’ “Wasn’t everybody expecting something to happen to Jake tonight?” Hinch asked. “I mean, the entire industry was probably expecting it. Our guy got suspended for an unintentional act, and they got a free shot.”It’s a confusing time. Either the players govern the players on the field like it’s always been, or we legislate it to where none of this crap happens. They got a free shot at him with no warning, no ejection. We’ll see if there’s discipline, and without discipline, there’s not going to be any issue doing it the next time. So if retaliations are in, cool. We’re well aware.”Marisnick, meanwhile, wouldn’t reveal whether he thought Ramirez’s pitch was intentional. Marisnick said: “That’s a question for him. I’m not the one throwing the baseball.” He added: “It’s not what I wanted. It was an unfortunate play back in Houston. I feel terrible about it. And to come here and have some of this go down, it sucks.”Jake Marisnick on getting hit by the pitch: “It was a little high, a little inside.”Wouldn’t say if he thought it was intentional: “That’s a question for him.” pic.twitter.com/YadlGzbe8t- Jack Harris (@Jack_A_Harris) July 17, 2019As for Ramirez? He denied hitting Marisnick intentionally.”I was just trying to sneak a fastball by him,” he said. “I tried to sneak one by him in, and it just got away from me.” The Angels hit Jake Marisnick (@JSMarisnick) who does everything he can to not let the situation escalate and it didn’t. pic.twitter.com/0CtbUScsBB- Mark Berman (@MarkBermanFox26) July 17, 2019″This was not a surprise,” Astros manager A.J. Hinch told reporters (via MLB.com). “I wish they would’ve handled it better. [The pitch] was too high. If they’re gonna hit guys, they need to hit guys the right way.”Finger-waggin’ Albert Pujols was about to take on the Astros dugout by himself. pic.twitter.com/IeLCQ7ZKqt- Fabian Ardaya (@FabianArdaya) July 17, 2019Hinch expressed his displeasure, accusing Ramirez of intentionally hitting Marisnick and claiming it was “a free shot.” Tuesday’s game marked Marisnick’s first game against the Angles since he collided with Los Angeles catcher Jonathan Lucroy at home plate, leaving Lucroy with a concussion and a broken nose. Related News The Angels plunked Astros outfielder Jake Marisnick on Tuesday in what may have been considered retaliation.The incident happened during the sixth inning, leading players on both teams to clear their benches after Noe Ramirez threw a pitch that hit Marisnick. Both sides were given a warning as a heated verbal exchange broke out between Angels first baseman Albert Pujols and Astros pitchers Lance McCullers Jr. and Justin Verlander, among others in Houston’s dugout. Update: Ramirez was suspended for three games for his actions while manager Brad Ausmus was suspended for one, MLB announced Wednesday.Noé Ramirez of the Angels has received a three-game suspension and an undisclosed fine for throwing a pitch in the area of the head of Jake Marisnick. In addition, Angels manager Brad Ausmus has received a one-game suspension.- Brian McTaggart (@brianmctaggart) July 17, 2019Ramirez will appeal.”Didn’t necessarily like it but it is what is,” he said, via the Los Angeles Times.On his suspension, #Angels Noe Ramirez said, “Didn’t necessarily like it but it is what is.” He is appealing it.- Maria Torres (@maria_torres3) July 17, 2019
Would you ever go on vacation to the North Pole? Unless you like subzero temperatures and Nordic-ski treks, probably not. But if you lived 56 million years ago, you might answer differently. Back then, you would have enjoyed balmy temperatures and a lush green landscape (although you would have had to watch out for crocodiles). That’s because the world was in the middle of an extreme period of global warming called the Paleo-Eocene Thermal Maximum, when the Earth was so hot that even the poles reached nearly tropical temperatures. But was the planet ever as hot as it is today, when every month the globe seems to be breaking one high-temperature record after another? It turns out that the Earth has gone through periods of extreme warming more than once. The poles have frozen and thawed and frozen again. Now, the Earth is heating up again. Even so, today’s climate change is a different beast, and it’s clearly not just part of some larger natural cycle, Stuart Sutherland, a paleontologist at the University of British Columbia, told Live Science. [How Often Do Ice Ages Happen?] AdvertisementIs It OK to Throw House Spiders Outside?Some gentle souls will trap spiders in a jar and release them outside, waiting for them to scurry away. But is this outdoor relocation an act of compassion, or a death sentence for the spider?Your Recommended PlaylistVolume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9接下来播放Are Santa’s Reindeer Males?01:36关闭选项Automated Captions – en-US facebook twitter 发邮件 reddit 链接https://www.livescience.com/65927-has-earth-been-this-hot-before.html?jwsource=cl已复制直播00:0001:2701:27 What is a Carbon Sink? What If a Giant Asteroid Had Not Wiped Out the Dinosaurs? Earth’s climate does naturally oscillate — over tens of thousands of years, its rotations around the sun slowly change, leading to variations in everything from seasons to sunlight. Partially as a result of these oscillations, Earth goes through glacial periods (better known as ice ages) and warmer interglacial periods. But to create a massive warming event, like the Paleo-Eocene Thermal Maximum, it takes more than a change in the tilt of Earth’s axis, or the shape of its path around the sun. Extreme warming events always involve the same invisible culprit, one we’re all too familiar with today: a massive dose of carbon dioxide, or CO2. This greenhouse gas was almost certainly responsible for the Paleo-Eocene Thermal Maximum. But how did CO2 concentrations get so high without humans around? Scientists aren’t absolutely sure, said Sébastien Castelltort, a geologist at the University of Geneva. Their best guess is that volcanoes spewed carbon dioxide into the atmosphere, trapping heat, and perhaps melting frozen pockets of methane, a greenhouse gas more potent than CO2 that had been long sequestered under the ocean. Just because extreme warming events spurred by greenhouse gases have happened before, doesn’t mean these events are harmless. Take, for instance, the Permian-Triassic extinction event, which struck a few million years before dinosaurs arose on the planet. If the word “extinction” isn’t enough of a clue, here’s a spoiler: it was an absolute disaster for Earth and everything on it. This warming event, which occurred 252 million years ago, was so extreme that Sutherland calls it the “poster child for the runaway greenhouse effect.” This warming event, which was also caused by volcanic activity (in this case, the eruption of a volcanic region called the Siberian Traps), triggered climate chaos and widespread death. “Imagine extreme drought, plants dying, the Saharah spreading throughout the continent,” Sutherland told Live Science. Temperatures rose 18 degrees Fahrenheit (10 degrees Celsius). (This is compared with the 2.1 F (1.2 C) rise in temperature we’ve seen since humans began burning fossil fuels). Around 95% of marine life and 70% of terrestrial life went extinct. “It was just too hot and unpleasant for creatures to live,” Sutherland said. It’s uncertain how high greenhouse gas concentrations were during the Permian-Triassic extinction event, but they likely were far higher than they are today. Some models suggest they grew as high as 3,500 parts per million (ppm). (For perspective, today’s carbon dioxide concentrations hover a little over 400 ppm — but that’s still considered high). But it’s the rate of change in CO2 concentrations that makes today’s situation so unprecedented. During the Permian Triassic extinction event, it took thousands of years for temperatures to rise as high as they did — according to some studies, as many as 150,000 years. During the Paleo-Eocene Thermal Maximum, considered an extremely rapid case of warming, temperatures took 10,000 to 20,000 years to reach their height. Today’s warming has taken only 150 years. That is the biggest difference between today’s climate change and past climatic highs. It’s also what makes the consequences of current climate change so difficult to predict, Castelltort said. The concern isn’t just “but the planet is warming.” The concern is that we don’t know how rapid is too rapid for life to adjust, he said. Based on past warming events, no experts could possibly say that the current rate of warming won’t have dramatic consequences, he said. “We just don’t know how dramatic,” he added. Why Weather Affects Climate Change Belief Originally published on Live Science.by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeVikings: Free Online GamePlay this for 1 min and see why everyone is addicted!Vikings: Free Online GameUndoTruthFinder People Search SubscriptionOne Thing All Liars Have in Common, Brace YourselfTruthFinder People Search SubscriptionUndoGundry MD Total Restore SupplementU.S. Cardiologist: It’s Like a Pressure Wash for Your InsidesGundry MD Total Restore SupplementUndoKelley Blue Book2019 Lexus Vehicles Worth Buying for Their Resale ValueKelley Blue BookUndoFinance DailySeniors With No Life Insurance May Get Up To $250,000 If They Do This…Finance DailyUndoCNETMeet the US Navy’s new $13 billion aircraftCNETUndo
Originally published on Live Science.by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeVikings: Free Online GamePlay this for 1 min and see why everyone is addicted!Vikings: Free Online GameUndoTruthFinder People Search SubscriptionOne Thing All Liars Have in Common, Brace YourselfTruthFinder People Search SubscriptionUndoGundry MD Total Restore SupplementU.S. Cardiologist: It’s Like a Pressure Wash for Your InsidesGundry MD Total Restore SupplementUndoNucificTop Dr. Reveals The 1 Nutrient Your Gut Must HaveNucificUndoArticles VallyDad Cuts Daughter’s Hair Off For Getting Birthday Highlights, Then Mom Does The UnthinkableArticles VallyUndoBirch Gold GroupThis IRS Tax Law is Sweeping the U.S.Birch Gold GroupUndo 7 Odd Things That Raise Your Risk of Cancer (and 1 That Doesn’t) A simple cold virus could wipe out tumors in a form of bladder cancer, a small new study suggests. Though the idea of using viruses to fight cancer isn’t new, this is the first time a cold virus effectively treated an early-stage form of bladder cancer. In one patient, it eliminated a cancerous tumor, the group reported July 4 in the journal Clinical Cancer Research. A group of researchers conducted an early-stage clinical trial in which they infected 15 bladder cancer patients with coxsackievirus A21, which is one of the viruses that cause the common cold. Coxsackievirus is not a genetically modified virus; it’s “something that occurs in nature,” said senior author Hardev Pandha, a professor of medical oncology at the University of Surrey in England. [Exercise May Reduce the Risk of These 13 Cancers]Headbutting Tiny Worms Are Really, Really LoudThis rapid strike produces a loud ‘pop’ comparable to those made by snapping shrimps, one of the most intense biological sounds measured at sea.Your Recommended PlaylistVolume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9接下来播放Why Is It ‘Snowing’ Salt in the Dead Sea?01:53 facebook twitter 发邮件 reddit 链接https://www.livescience.com/65908-cold-virus-might-treat-bladder-cancer.html?jwsource=cl已复制直播00:0000:3500:35 The researchers gave the patients the virus through catheters that the patients already had inserted for other treatments. They left the virus-filled catheter in for an hour to pump the fluids into the bladder and repeated this treatment. Then, the patients underwent surgery to remove what was left of their bladder tumors. In one patient, the virus completely destroyed the tumor. In all of the other patients, the researchers found evidence that the virus had damaged the tumors and had spurred the immune system to send an army of immune cells to the tumors. None of the patients had any significant side effects, Pandha said. Researchers thought this method would work because the outer membranes of cancerous bladder cells contain a gateway for the coxsackievirus: a molecule called ICAM-1. Because healthy cells don’t carry this molecule, the coxsackievirus doesn’t attack them. Once the virus gets into the cell, it hijacks the cell’s machinery and ends up killing it. Even more cancer cells die when the immune cells are recruited. ICAM-1 is also expressed by other cancer cells, and coxsackievirus has, in fact been previously shown to be effective in treating very advanced bladder cancer and other cancers, such as melanoma, Pandha said. Even so, this is still an early-stage trial, and there’s still a long way to go before the method can be used in treatment, Pandha said. “This would be the foundation for much larger studies where we’d build on this,” he said. Newer studies will try to make the treatment more effective and stop the cancer from coming back, he added. Unfortunately, just getting a common cold won’t treat the cancer on its own. Pandha’s team gave a much higher dose of the virus than you would get if someone coughed on you and you got sick, for example. Interestingly, the patients who were given the virus through the catheter did not get cold symptoms. “I agree that [such viruses are] good therapeutic target[s]” for certain types of cancers, like bladder cancer, said Grant McFadden, director of the Biodesign Center for Immunotherapy, Vaccines and Virotherapy at Arizona State University, who was not a part of the study. But he noted that many studies have looked at whether viruses can target cancer cells. In fact, a host of viruses have been studied for attacking bladder cancer, specifically. It’s likely that many viruses will work well to treat bladder cancer and at least some tumor-destroying viruses “will get approved for use in humans,” McFadden told Live Science. “But this paper isn’t really new or innovative.” In fact, the idea of using viruses to treat cancer goes back nearly 100 years, Pandha said, but only in the past decade or so has it gained momentum. Editor’s note: This article was updated. Only a couple of the authors (not Pandha) are employed by Viralytics, a Merck-owned biotech company that is developing viral-based cancer treatments. Colorful But Deadly: Images of Brain Cancer 7 Side Effects of Cancer Treatment, and How to Cope with Them
Cyclone Gaja: DMK leaders to contribute one month salary towards relief activities Published on Tamil Nadu COMMENT cyclones SHARE SHARE EMAIL RELATED When perennial crops fall prey to nature’s fury… Tamil Nadu Chief Minister K Palaniswami surveys the damage caused by Cyclone Gaja in Pudukottai and Thanjavur districts, on November 20, 2018 – Twitter/@CMOTamilNadu Tamil Nadu Chief Minister K Palaniswami on Tuesday visited the districts hit by Cyclone Gaja, distributed relief materials among the affected people and indicated he would meet Prime Minister Narendra Modi later this week to seek central assistance.“We have sought appointment with him (Modi). We expect that it could be given day after tomorrow (Thursday). The state government will certainly take steps to get central funds and submit details of the damage with proof,” Palaniswami told reporters here during his visit to Pudukottai and Thanjavur districts in the morning. The cyclone crossed the coast near Vedaranyam in Nagapattinam district, about 300 km from Chennai, with a speed of up to 120 kmph last Friday, claiming 46 lives and leaving a trail of destruction in over 10 districts in southern Tamil Nadu. Meanwhile, relief work was hampered after various parts of the Cauvery delta region, including the cyclone-hit Nagapattinam and Thiruvarur districts, were lashed by heavy rains since Tuesday morning. The weather office has forecast heavy rains in the region under the influence of a well-marked low pressure in the Bay of Bengal. Amid criticism of his government’s handling of the situation, the Chief Minister, who announced a Rs 1,000-crore package on Monday for immediate relief and rehabilitation work, urged the Opposition to bury political differences and contribute towards the relief activities. Citing the recent devastating floods in Kerala, Palaniswami said the Opposition there raised no issues then, though it took about a month for the relief activities to be completed. “Everyone should go by their conscience and do their bit in helping the affected people,” Palaniswami said. On the people’s anger over alleged tardy relief works in some places, he said it was due to the government’s precautionary measures that loss of lives had been minimised. None can predict the magnitude of a natural phenomenon and ‘Gaja’ has left a huge trail of destruction, the Chief Minister said, adding that the government was taking steps on a war-footing to address the people’s issues. Earlier, accompanied by ministers and officials, Palaniswami inspected some coconut groves devastated by the cyclone in Thanjavur district and also distributed relief materials, including rice and other essential articles, to the affected people. At Pattukottai, he distributed Rs 30 lakh as compensation to a woman, who lost all her three sons in a wall collapse in the wake of the cyclone. The state government had announced a Rs 10-lakh solatium to the kin of those killed in the cyclone. A report from Nagapattinam said several areas in the district including Vedaranyam and Sirkazhi were experiencing intermittent heavy rains, affecting the relief operations. Protests by the public were reported in some places demanding supply of drinking water and restoration of electricity supply. On Monday, Palaniswami took stock of the situation at a high-level meeting in Chennai and announced an immediate cash assistance totalling Rs 8,800 to each family sheltered in relief camps, besides 10-kg rice and four litres of kerosene. Palaniswami had said the toll in the cyclone has risen to 46, while as many as 2,51,674 people were staying in relief camps. SHARE Cyclone update: Gaja to intensify by 3 pm Cyclone Gaja: Death toll rises to 45 November 20, 2018 COMMENTS
Published on February 14, 2019 COMMENT Delhi SHARE SHARE EMAIL West Bengal Chief Minister Mamata Banerjee and Delhi CM Arvind Kejriwal (file photo) – PTI The Aam Aadmi Party is keen on an alliance with the Congress in Delhi, West Bengal Chief Minister Mamata Banerjee claimed on Thursday.It is now up to the Congress to reciprocate, she said. “Arvind Kejriwal (Delhi chief minister and AAP chief) wants an alliance with the Congress in Delhi,” Banerjee, who is also the Trinamool Congress chief, told reporters.Banerjee said she respected the decision of political parties which cannot take a call on pre-poll alliance because of political compulsions.Earlier in the day, Kejriwal said the Congress had “more or less” declined to have an alliance in Delhi.He also said the BJP will benefit in a three-cornered fight in the national capital. Kejriwal’s remark came a day after he had participated in a meeting with opposition leaders, including Congress president Rahul Gandhi. state politics SHARE COMMENTS
Jammu and Kashmir National Conference (JKNC) Vice- President Omar Abdullah – PTI National Conference (NC) vice-president Omar Abdullah Thursday said cases registered against Jammu and Kashmir youth since 2015, after the PDP-BJP alliance came to power in the state, would be reviewed and the FIRs cancelled if his party is voted to power.Addressing an election meeting here in Chijhama village of Rafiabad in north Kashmir’s Baramulla district, Abdullah said he wanted to create an atmosphere in Jammu and Kashmir where people could talk freely.“There are cases against our youth under which they are called to police stations even today. The NC government will review each case, one by one, registered against our youth right since 2015 and especially of 2016 (unrest) and afterwards and cancel their FIRs so that our youth are set free,” he said.Cases were registered against several youths in the valley during the unrest which followed the killing of Hizbul Mujahideen commander Burhan Wani in an encounter with security forces in Kokernag area of south Kashmir’s Anantnag district in July 2016. “We want to attract our people towards us, we want such a situation here where we can talk to each other freely and address the problems of this state. I want to see that day when we would not need this (concertina) wire and rope when we come to see each other, when we would not need policemen or security,” the NC leader said.“(I want to see) a day when if I make some mistake, you would come and hold my collar and ask me, ‘Omar, we had given you an opportunity to serve us and represent us but why didn’t you’ We want return of that Kashmir which has been snatched from us,” Abdullah said.Referring to the state’s accession with the Union of India, he said the NC wanted restoration of terms agreed upon by the two sides at that time.“We want restoration of those powers on the basis of which our accession took place and which have been gradually taken (away) from us and against which conspiracies are going on even today,” he said.Hitting out at Peoples Democratic Party (PDP) president and former chief minister Mehbooba Mufti, Abdullah said the people of Jammu and Kashmir could not rely on her for safeguarding the state’s special status.“I was in the parliament when a debate was going on (ahead of trust vote in July 2008) and two members were given the opportunity to talk about the state — me and Mehbooba. I spoke for about five minutes and said whatever I could, but when the Speaker asked Mehbooba to speak, she said ‘what can I say?’ and sat down. Do we need such representatives who go there and stay silent?” he asked the gathering.He said the NC is the only party which can safeguard Jammu and Kashmir’s special status.Abdullah also reiterated his promise of revoking the controversial Public Safety Act (PSA) in the state if his party returns to power.“The NC has made a promise to the people of the state to remove PSA under which our youth are arrested. If God wills and NC forms the government, I promise you that we will remove this law. I am not saying that we will not use it, because if someone else comes after me, then he will use it,” he said.Abdullah asserted that his party would fulfil its promise unlike the PDP.“We will not even change its (PSA) nomenclature like the pen and inkpot people (party symbol of the PDP) did with (special) task force. In 2002, Sayeed said they will disband the task force. But what did he do after he came to power? He changed its name but kept it as it was. It has same functions and same officers, but a new name like old wine in new bottles,” he said.“We will not change PSA’s name, we will wipe it out from this state so that our elders and mothers do not need to go to police stations to look for their children,” he said. COMMENTS Published on April 04, 2019 SHARE COMMENT SHARE SHARE EMAIL Elections 2019 Referring to the state’s accession with the Union of India, he said the NC wanted restoration of terms agreed upon by the two sides at that time. Jammu and Kashmir
national elections 0 COMMENT May 18, 2019 Published on SHARE SHARE EMAIL Bihar Congress President Rahul Gandhi with the party’s Patna Sahib parliamentary constituency seat candidate Shatrughan Sinha during a roadshow for the final phase of Lok Sabha general elections in Patna on Thursday. Photo: Ranjeet Kumar/ The Hindu – THE HINDU SHARE As many as four union ministers are among the 157 candidates in Bihar, whose electoral fortunes will be decided on Sunday in the final phase of general elections.About 1.52 crore voters will exercise their franchise in the eight Lok Sabha constituencies – Patna Sahib, Pataliputra, Arrah, Buxar, Karakat, Sasaram, Nalanda and Jehanabad – at 15,811 booths, according to figures made available by the Election Commission.Seven of these seats were won by the NDA last time, five by the BJP and two by the RLSP, which is now with the ‘Mahagathbandhan’.One was bagged by the JD(U) headed by Chief Minister Nitish Kumar, which then fought separately but is now back with the NDA.A by-poll will also be held for the Dehri Assembly seat, which fell vacant last year upon the disqualification of RJD MLA and former state minister Mohd Ilyas Husain, who was convicted in the bitumen scam by a Ranchi court.The most keenly-watched contest is in Patna Sahib, where Ravi Shankar Prasad, one of the most prominent members of the Narendra Modi cabinet, is seeking entry into the Lok Sabha. The BJP has won the seat in both the elections that have taken place since it came into being after the 2008 delimitation.However, Prasad faces the challenge of retaining the seat for his party by defeating Shatrughan Sinha – the actor- turned-politician – who won it on both occasions and is now in the fray as the Congress candidate.The neighbouring Pataliputra has become a prestige issue for the family of RJD supremo Lalu Prasad, which has contested the seat twice, losing on both occasions to his former loyalists.While Prasad himself lost to JD(U)’s Ranjan Yadav, his daughter Misa Bharti was defeated by Ram Kripal Yadav, who fought on a BJP ticket and became a Union minister. Bharti is once again in the fray against Yadav.Arrah is witnessing a battle of ideological extremes as union minister RK Singh, an IAS officer, who retired as the Union Home secretary before joining the BJP and making his electoral debut five years ago, seeks to retain the seat overcoming the challenge posed by Raju Yadav of the CPI(ML).Yadav’s prospects have been boosted with the RJD-led Mahagathbandhan supporting his candidature and the ultra-Left party has reciprocated the gesture by supporting Misa Bharti in Pataliputra.In Buxar, Union minister Ashwini Kumar Choubey’s bid to retain the seat for the second consecutive term has been challenged by veteran RJD leader Jagadanand Singh, who has represented the Lok Sabha constituency formerly and, unlike the incumbent, who hails from Bhagalpur, is seen as a “local“.Karakat is where RLSP chief Upendra Kushwaha made a successful Lok Sabha debut five years ago as an NDA ally and went on to become a Union minister only to part ways in December last year when he joined the Mahagathbandhan.His bid to retain the seat faces a stiff challenge from JD(U)’s Mahabali Singh, who finished third last time but was the winner in 2009 when his party was with the NDA.Former Lok Sabha Speaker and veteran Congress leader Meira Kumar is in the fray from Sasaram, which she had represented two times on the trot before losing to BJP’s Chhedi Paswan in 2014.Paswan, who had formerly been the MP from the seat in 1989 and 1991 on a Janata Dal ticket, has once again been fielded by his party. Kumar’s father, former Deputy Prime Minister Jagjivan Ram, had represented the reserved seat several times, mostly on a Congress ticket and twice as a Janata Party’s candidate.In Nalanda, second term JD(U) MP Kaushalendra Kumar – a confidant of the Chief Minister, who retained the seat for the party in 2014 surmounting the Modi wave – is once again in the fray.His bid has been challenged by Ashok Kumar Azad Chandravanshi, who has been fielded by Hindustani Awam Morcha of Jitan Ram Manjhi – a former Chief Minister, who floated his own outfit after quitting the JD(U), started off as an NDA partner but ended up with the Mahagathbandhan.Jehanabad was won by RLSP’s Arun Kumar, but he was expelled by the party and went on to float his own outfit, which neither the NDA nor the Mahagathbandhan agreed to back. His bid to retain the seat is meeting with a two-pronged challenge from RJD’s Surendra Yadav – an MLA from the adjoining district of Gaya, who is notorious for a strong-arm style of politics – and JD(U)’s Chandreshwar Prasad Yaduvanshi.Another notable candidate in Jehanabad is Angesh Kumar – a rebel candidate initially backed by Lalu Prasad’s disgruntled elder son Tej Pratap Yadav, who later pulled back in the larger interest of his father’s party. COMMENTS